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Constantine “Dean” Karvellas, MD, SM, FRCPC, FCCM

Associate Professor of Medicine (Critical Care Medicine and Gastroenterology/Hepatology) and  Adjunct Professor in the School of Public Health Sciences, University of Alberta


Dean has been an attending intensivist in the E. Garner King General Systems Intensive Care Unit since 2009 and is involved with the liver transplant program as a hepatologist. He is the only Canadian co-investigator in the NIH-funded United States Acute Liver Failure study group (US ALFSG). He is also a vice chair of the Society of Critical Care Medicine (SCCM) liver management task force. Dean has over 90 peer-reviewed publications reflecting his research interests in acute liver failure (ALF), acute on chronic liver failure (ACLF), liver transplantation and extracorporeal liver support.


Christopher Rose, PhD

Professor, Department of Medicine, Université de Montréal,

Director, Neuro-Hepato Laboratory, University Hospital Research Centre

Christopher’s research interests lie within the area of hepatic encephalopathy (HE), a field in which he has been researching for over 25 years. HE, a major neuropsychiatric complication of liver disease, touches close to 80% of patients with cirrhosis affecting their quality of life and resulting in significant socioeconomic burden, morbidity and mortality both pre and post-liver transplant. Translational research is the primary objective of Dr. Rose’s laboratory and, therefore, his research program is based on a bench-to-bedside concept. Dr. Rose has a vested interest in identifying the pathogenic factors and the pathophysiological pathways involved in the development of cerebral complications associated with liver disease which ultimately will lead to novel therapeutic approaches, improving the management of patients with liver disease as well as neurological outcome post-liver transplantation. 


Todd Frederick, MD

Transplant Hepatologist, San Francisco Center for Liver Disease, California Pacific Medical Center


Todd currently serves as clinical director of hepatology, fellowship director for transplant hepatology and chair of the Clinical Protocols Committee for the division. He received his undergraduate degree in biology from the University of California, Los Angeles and his medical degree from New York Medical College in Valhalla, New York.  He completed both his internal medicine residency and his fellowship in gastroenterology/hepatology at the University of California, San Diego. His clinical and research interests include the management of advanced chronic liver disease and liver failure, artificial liver support systems and portal hypertension, among other topics.

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