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Massimiliano Paganelli, MD, PhD​

Pediatric transplant hepatologist, head of the Hepatology and Cell Therapy Lab at Sainte-Justine UHC, assistant professor of pediatrics at Université de Montréal, Max earned his medical degree at the Sapienza University of Rome, he trained in pediatrics in Rome and in pediatric hepatology and transplant in Naples and in Brussels. Max has a Ph.D. in Hepatology and Cell Therapy from the Catholic University of Louvain. Expert in cell therapy of liver diseases, he is a Stem Cell Network (“SCN”) investigator and a CIHR/FRQS-funded scientist. Driven by the needs of the young patients he takes care of, Max is seeking better ways to treat liver disease using novel stem cell therapies. With his team at Sainte-Justine UHC, he developed the Encapsulated Liver Tissue, on which Morphocell Technologies’ ReLiver™ technology is based.

Constantine “Dean” Karvellas, MD, SM, FRCPC, FCCM


Dr. Constantine (Dean) Karvellas is an Associate Professor of Medicine (Critical Care Medicine and Gastroenterology/Hepatology) at the University of Alberta and an Adjunct Professor in the School of Public Health Sciences. He has been an attending intensivist in the E. Garner King General Systems Intensive Care Unit since 2009 and is involved with the Liver Transplant program as a Hepatologist. Dr. Karvellas is the only Canadian co-investigator in the NIH-funded United States Acute Liver Failure study group (US ALFSG). He is also a Vice Chair of the Society of Critical Care Medicine (SCCM) Liver management task force. Dr. Karvellas has over 90 peer-reviewed publications reflecting his research interests in acute liver failure (ALF), acute on chronic liver failure (ACLF), liver transplantation and extracorporeal liver support.

Christopher Rose, PhD

Dr. Christopher Rose is currently Professor in the Department of Medicine at the Université de Montréal and director of the Neuro-Hepato laboratory at the University Hospital Research Center (CRCHUM). Dr. Rose’s research interests lie within the area of hepatic encephalopathy (HE), a field in which he has been researching for over 25 years. HE, a major neuropsychiatric complication of liver disease, touches close to 80% of patients with cirrhosis affecting their quality of life and resulting in significant socioeconomic burden, morbidity and mortality both pre and post-liver transplant. Translational research is the primary objective of Dr. Rose’s laboratory and, therefore, his research program is based on a bench-to-bedside concept. Dr. Rose has a vested interest in identifying the pathogenic factors and the pathophysiological pathways involved in the development of cerebral complications associated with liver disease which ultimately will lead to novel therapeutic approaches, improving the management of patients with liver disease as well as neurological outcome post-liver transplantation. Dr. Rose’s laboratory is currently funded by the Canadian Institute of Health Research, the Canadian Liver Foundation, and the Québec Health Research Foundation (FQRS). Dr. Rose has published over 75 scientific articles and over 60 students at all levels from throughout the world have trained in his laboratory. Dr. Rose is currently co-chair of the Research Committee of the Canadian Association for the Study of the Liver and an executive committee member of the International Society for Hepatic Encephalopathy and Nitrogen Metabolism.

Todd Frederick, MD


Dr. R. Todd Frederick is a transplant hepatologist with the San Francisco Center for Liver Disease at California Pacific Medical Center.  He currently serves as Clinical Director of Hepatology and Fellowship Director for Transplant Hepatology as well as the Chair of the Clinical Protocols Committee for the Division. Dr. Frederick received his undergraduate degree in Biology from the University of California, Los Angeles and his medical degree from New York Medical College in Valhalla, New York.  He completed both his Internal Medicine Residency and his Fellowship in Gastroenterology/Hepatology at the University of California, San Diego. His clinical and research interests include the management of advanced chronic liver disease and liver failure, artificial liver support systems, and portal hypertension, among other topics.